A synthetic peptide for use as a blocking control in assays to test for specificity of PCBP1 antibody, Alternative Names: PCBP1 control peptide, PCBP1 antibody Blocking Peptide, Anti-PCBP1 Blocking Peptide, Poly rC binding protein 1 Blocking Peptide, PCBP1, PCBP-1, PCBP 1, PCBP-1 Blocking Peptide, PCBP 1 Blocking Peptide
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
PCBP1
(Poly(rC) Binding Protein 1 (PCBP1))
Sujet
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.